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La Roche-Posay Redermic R ($56, laroche-posay.us). The skin-rebuilding retinol and exfoliating lipohydroxy acid in this creamy serum help lessen the effects of past sun damage. "It smooths my fine lines and heals dry patches," a fan reported.
Runner up:
DERMAdoctor Wrinkle Revenge Lift and Replenish Serum ($65, Ulta stores)