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Having sex is definitely pleasurable on a physical level, but chemically it has been suggested to elevate mood and reduce depression.
The surmised reason, believe it or not: Exposure to semen. A study done by the State University of New York controlled the length of a relationship, amount of sex, time elapsed since last sexual encounter, and use of oral contraceptives to show that women who never used condoms reported better moods and fewer depressive symptoms or suicidal thoughts than those who used condoms. Why? One theory is that vaginal tissue is very absorptive, and semen contains a host of mood-elevating chemicals, like endorphins, oxytocin, serotonin, and prolactin. For women, sex is literally a jolt to your system, and if you're getting it on regularly you might be on cloud nine for quite a while.