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Mizuno Wave Creation 11
The plastic "wave" midsole in this lightweight shoe takes cushioning up a notch by absorbing impact along your entire foot, thereby creating ouch-free landings for joints. Plus, its underfoot ventilation system prevents overheating, and a soft sock liner keeps feet sweat- and odor-free. "Absolute comfort!" one tester says. "My struggle to find the perfect shoes is over." ($135, zappos.com)
Footnote: If you've got high arches, like tester Carrie Carlson, 29, chances are you need more cushioning than stability in your sneaks. "It was as if the Mizunos were made for my feet; they had me running like a gazelle," says Carrie, who jogs after work along New York City's East River.